[All-postdocs] Bioseminar Thursday 1/13 - Bryan James, WHOI Postdoc

[Ana M Velez]

Biology Department Virtual Seminar

Thursday, January 13, at Noon.

Dr. Bryan James, Postdoctoral Scholar, Department of Marine Chemistry and Geochemistry, WHOI

Engineering Complex Microenvironments and Their Applications to Sex-Specific Mechanobiology and Biomaterial Development

The cellular microenvironment is a combination of biological interactions, chemical factors, and mechanical stimuli. All of these have been investigated in vitro individually; however, the in vivo environment exposes cells to all of these at the same time. This leads to synergistic and antagonistic effects between biologics, chemicals, and mechanics. My work engineered the needed instrumentation for studying complex mechanical stimuli (shear stress, cyclic stretch, hydrostatic pressure, and material properties), to evaluate the sex-specific response to complex stimuli using the vascular niche as a model microenvironment, and to develop biomaterials that stimulate cells using DNA aptamer-collagen complex systems for hard (bone) and soft (vascular) tissue engineering. Collectively, this work demonstrates the need to appreciate the complex interactions of biologics, chemical factors, and mechanical stimuli in regulating cell fate and in biomaterials design. I conclude by relating how biomaterials science can support environmental science to address the potential impacts of plastic pollution.

Zoom link will be provided after registering at: https://whoi-edu.zoom.us/meeting/register/tJYldeygqzMsH9dF3my_95gUDYxf7y42qACE

Ana Maria Velez
Administrative Associate
Biology Department - WHOI

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