[All-postdocs] Biology Seminar this Thursday: Dr. Drew Gorman-Lewis, University of Washington

[Margot McKlveen]

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*Biology Department Virtual Seminar*

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Thursday, April 22 at Noon

Zoom link: 
https://whoi-edu.zoom.us/j/91874164417?pwd=SzBKcGZvWjFUVTA2YmY3VDlZNVd0UT09 
<https://whoi-edu.zoom.us/j/91874164417?pwd=SzBKcGZvWjFUVTA2YmY3VDlZNVd0UT09>


Dr. Drew Gorman-Lewis, Associate Professor

University of Washington - Department of Earth and Space Sciences


Diving Into the Surface Properties of Ammonia Oxidizing Microbes and 
Their Affinity for Copper

Molecular adaptations of microbial surfaces may aid in nutrient 
acquisition in oligotrophic environments. Nutrient-cell interactions 
that are thermodynamically favored over interactions with non-nutrient 
solutes could be extremely advantageous when essential nutrients are 
limited. The ammonia-oxidizing archaeon (AOA) Nitrosopumilus maritimus 
strain SCM1 (N. maritimus), a representative of the Thaumarchaeota 
archaeal phylum, can sustain high specific rates of ammonia-oxidation at 
ammonia concentrations too low to sustain metabolism by 
ammonia-oxidizing bacteria (AOB). AOA and AOB oxidize ammonia to 
hydroxylamine using homologs of the metalloenzyme ammonia monooxygenase, 
which requires Cu(II) as an essential cofactor for its catalytic 
function. One structural and biochemical difference between N. maritimus 
and AOB is the cell surface. A proteinaceous surface layer (S-layer) 
comprises the outermost boundary of the N. maritimus cell envelope, as 
opposed to the lipopolysaccharide coat of Gram-negative AOB. In this 
work, we characterized the surface affinity of N. maritimus and 
representative AOB with Cu(II) using surface complexation modeling and 
isothermal titration calorimetry.  Aqueous speciation calculations with 
thermodynamic parameters derived from the models suggest that the cell 
surface of N. maritimus confers a distinct advantage in acquiring Cu(II) 
over AOB.


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https://whoi-edu.zoom.us/j/91874164417?pwd=SzBKcGZvWjFUVTA2YmY3VDlZNVd0UT09 
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-- 
Margot McKlveen | she/her
Senior Administrative Assistant
Woods Hole Oceanographic Institution
Redfield Building Room 305 | MS 32
266 Woods Hole Rd.
Woods Hole, MA 02543
508-289-2334
mmcklveen at whoi.edu

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