[All-postdocs] Biology seminar next week: José Pablo Vázquez-Medina, UC-Berkeley

[Margot McKlveen]

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*Biology Department Virtual Seminar*

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Thursday, July 15 at Noon

Zoom link: https://whoi-edu.zoom.us/j/95561978308 
<https://whoi-edu.zoom.us/j/95561978308>


Dr. José Pablo Vázquez-Medina

Assistant Professor, University of California, Berkeley


Chasing the Mechanistic Bases of Stress Adaptation in Northern Elephant 
Seals

Elephant seals are a prime example of extreme physiological adaptation 
as they can hold their breath for extended periods while diving and 
sleeping. Remarkably, extended breath-holding in seals is associated 
with severe hypoxemia and ischemia but does not result in the 
cardiovascular complications observed in humans that suffer from heart 
attacks, pulmonary embolism, or sleep apnea. Similarly, elephant seals 
undergo spontaneous long-term absolute food deprivation while breeding, 
molting, and weaning. Prolonged fasting in elephant seals induces a 
pro-inflammatory phenotype and increases circulating cortisol without 
causing deleterious consequences. The cellular mechanisms that drive 
seals’ tolerance to such conditions, however, remain largely unknown. 
Hence, we have established physiologically relevant ex vivo systems, 
including contractile myofibers and flow-adapted endothelial cells, to 
study how seal cells respond to different stressors and physiological 
adjustments associated with fasting and breath-holding. Here, I will 
present some data my lab has generated using those systems. Mechanistic 
studies using ex vivo systems along with traditional whole-organism 
investigations can help dissect the cellular and molecular bases of 
extreme physiological adaptation in elephant seals and other wild 
vertebrates.


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Meeting ID: 955 6197 8308

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-- 
Margot McKlveen | she/her
Senior Administrative Assistant
Woods Hole Oceanographic Institution
Redfield Building Room 305 | MS 32
266 Woods Hole Rd.
Woods Hole, MA 02543
508-289-2334
mmcklveen at whoi.edu

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