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<p class="MsoNormal"><span style="font-size:10.5pt;color:#3C4043;letter-spacing:.15pt;background:white">Woods Hole Oceanographic Institution</span><span style="font-size:10.5pt;color:#3C4043;letter-spacing:.15pt"><br>
<span style="background:white">Biology Department Seminar</span><br>
<span style="background:white">Thursday, October 26, 2023 – 12:00 Noon </span>
<br>
<br>
<b><span style="background:white">David Geller-McGrath</span></b><br>
<span style="background:white">WHOI-MIT Joint Program Student</span><br>
<br>
<b><span style="background:white">Metapathpredict: A Machine Learning-Based Tool for Prediction of Metabolic Modules in Incomplete Bacterial Genomes</span></b><br>
<span style="background:white">Microorganisms play a key role in all major biogeochemical cycles on Earth. Accurate and more complete identification of microbial metabolic pathways within genomic data is crucial to understanding their potential activities.
Together with assessment of gene expression, it is increasingly possible to gain important insight into feedbacks between microorganisms and the chemistry of their environment as well as into their interactions with other organisms. Reconstruction of complete
microbial metabolic pathways using ‘omics data from environmental samples remains challenging due to the incomplete nature of most genomic data for individual taxa. Computational pipelines for pathway reconstruction that utilize machine learning methods to
predict the presence or absence of KEGG modules in incomplete genomes are lacking. MetaPathPredict is a new software tool that incorporates machine learning models to predict the presence of complete KEGG modules within bacterial genomes using gene annotation
data and information from the KEGG module database. Benchmarks show that MetaPathPredict makes robust predictions of KEGG module presence in highly incomplete bacterial genomes. MetaPathPredict has also been applied to MAGs from poorly characterized candidate
phyla recovered from the Guaymas Basin deep subsurface. This new tool facilitates more complete and accurate reconstruction of the metabolic potential of bacterial genomes, which can inform analysis of environmental genomic datasets.</span><br>
<br>
<span style="background:white">HYBRID! <b> In person</b>: Clark 201 <b>Zoom</b>:
</span></span><a href="https://nam02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.google.com%2Furl%3Fq%3Dhttps%3A%2F%2Fwhoi-edu.zoom.us%2Fj%2F99399604868%26sa%3DD%26source%3Dcalendar%26ust%3D1698519292305723%26usg%3DAOvVaw0qSLTsw5QpCbJfe5_H2uBo&data=05%7C01%7Call-postdocs%40whoi.edu%7C0193a7f16e694cf590fb08dbd3fa2589%7Cd44c5cc6d18c46cc8abd4fdf5b6e5944%7C0%7C0%7C638336843555287092%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=b8jgIGB%2FOGRMUfpKeIs5xPlEKFpflZ%2FWYG4vwpccZ%2Bk%3D&reserved=0" originalsrc="https://www.google.com/url?q=https://whoi-edu.zoom.us/j/99399604868&sa=D&source=calendar&ust=1698519292305723&usg=AOvVaw0qSLTsw5QpCbJfe5_H2uBo" shash="a6Y4C6w5RSjmcMeb8WAuDCn4SbyuMoYreJEXWGgGNGm6Fby0qV7l2AEF3kEWbNx14g+/CCHcoXHtH6/WzAUbkZZTbSHVEDrBo3BidrfLQ3MlUBNXSmg4dsbf6rCxYdGWpJjIxEVa52UO5dbGe0fVLl3lec/lQvMKGzcDJP38bVY=" target="_blank"><span style="font-size:10.5pt;color:blue;letter-spacing:.15pt;background:white">https://whoi-edu.zoom.us/j/99399604868</span></a><span style="font-size:10.5pt;color:#3C4043;letter-spacing:.15pt;background:white">
Meeting ID: 993 9960 4868 <b>By phone</b>: Find your local number: </span><a href="https://nam02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.google.com%2Furl%3Fq%3Dhttps%3A%2F%2Fwhoi-edu.zoom.us%2Fu%2FaeH38NVF4H%26sa%3DD%26source%3Dcalendar%26ust%3D1698519292305723%26usg%3DAOvVaw3D8stMpvn5A1oTTiiOtbUZ&data=05%7C01%7Call-postdocs%40whoi.edu%7C0193a7f16e694cf590fb08dbd3fa2589%7Cd44c5cc6d18c46cc8abd4fdf5b6e5944%7C0%7C0%7C638336843555443355%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=ei7fj23vh5D%2F82XLlySLO9%2FqcZMCyHlumU%2FQUcXZ7vc%3D&reserved=0" originalsrc="https://www.google.com/url?q=https://whoi-edu.zoom.us/u/aeH38NVF4H&sa=D&source=calendar&ust=1698519292305723&usg=AOvVaw3D8stMpvn5A1oTTiiOtbUZ" shash="eJCKY6A1c6NutB481Jc99B+wgOry4q+YoQvRBkf4zD2QEMLtOlIIjsRwSxvYzmen2oeyg519T5VGvz0HdEyGHqFLQly1KBeushAJ+ukvjiwQz9kj8SzKG0SQzE1yk9A1IOPW56HUL1JBlEa5Da/ebxaR93wJJuScdIc6QRSgfYU=" target="_blank"><span style="font-size:10.5pt;color:blue;letter-spacing:.15pt;background:white">https://whoi-edu.zoom.us/u/aeH38NVF4H</span></a><o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">For questions, contact:<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:"Century Gothic",sans-serif;color:#4472C4">Ana María Vélez</span></b><span style="font-size:10.0pt;font-family:"Century Gothic",sans-serif;color:black"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:9.0pt;font-family:"Century Gothic",sans-serif;color:black">Administrative Associate<o:p></o:p></span></p>
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<p class="MsoNormal"><span lang="ES-CO" style="font-size:9.0pt;font-family:"Century Gothic",sans-serif;color:black">O: 508.289.2334<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="ES-CO" style="font-size:9.0pt;font-family:"Century Gothic",sans-serif;color:black">E:
</span><span style="font-size:9.0pt;font-family:"Century Gothic",sans-serif;color:black"><a href="mailto:ana.velez@whoi.edu"><span lang="ES-CO">ana.velez@whoi.edu</span></a></span><span lang="ES-CO" style="font-size:9.0pt;font-family:"Century Gothic",sans-serif;color:black"><o:p></o:p></span></p>
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